%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Tereza Kubasova, Lenka Davidova-Gerzova, Elodie Merlot, Matej Medvecky, Ondrej Polansky, Delphine Gardan-Salmon, Helene Quesnel, Ivan Rychlik
Housing Systems Influence Gut Microbiota Composition of Sows but Not of Their Piglets
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref006)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref007)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref008)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref009)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref010)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170051.ref011)>>
endobj
14 0 obj
[21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
endobj
21 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 628.3276 m
208.1764 628.3276 l
h
f*
538.2425 615.3449 m
543.0047 615.3449 l
h
f*
245.4803 550.3181 m
250.2425 550.3181 l
h
f*
351.0425 537.3354 m
355.8047 537.3354 l
h
f*
307.2756 485.348 m
316.8 485.348 l
h
f*
321.2787 485.348 m
330.7465 485.348 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(production)Tj
4.7168 0 Td
(conditions,)Tj
4.6998 0 Td
(the)Tj
1.4683 0 Td
(importance)Tj
4.8302 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(and)Tj
1.7291 0 Td
(environmental)Tj
6.1115 0 Td
(microbiota)Tj
4.6204 0 Td
(sources)Tj
-32.9893 -1.3039 Td
(may)Tj
1.9275 0 Td
(vary)Tj
1.9332 0 Td
(considerably.)Tj
5.5162 0 Td
(In)Tj
1.1112 0 Td
(pig)Tj
1.4683 0 Td
(production,)Tj
4.9436 0 Td
(the)Tj
1.4683 0 Td
(cleaning)Tj
3.5773 0 Td
(procedures)Tj
4.6715 0 Td
(applied)Tj
3.1521 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(farrowing)Tj
-32.275 -1.2982 Td
(unit)Tj
1.8595 0 Td
(prior)Tj
2.2563 0 Td
(to)Tj
1.0262 0 Td
(entrance)Tj
3.6907 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(sows)Tj
2.1316 0 Td
(decrease)Tj
3.6113 0 Td
(the)Tj
1.4684 0 Td
(occurrence)Tj
4.6601 0 Td
(of)Tj
1.0148 0 Td
(environmental)Tj
6.1115 0 Td
(microbiota.)Tj
-30.3135 -1.2983 Td
(Despite)Tj
3.2484 0 Td
(this,)Tj
1.8992 0 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8504 0 Td
(difficult)Tj
3.3505 0 Td
(to)Tj
1.0261 0 Td
(predict)Tj
3.0501 0 Td
(to)Tj
1.0261 0 Td
(what)Tj
2.16 0 Td
(extent)Tj
2.6816 0 Td
(the)Tj
1.4683 0 Td
(sows)Tj
2.1317 0 Td
(are)Tj
1.4513 0 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(develop-)Tj
-32.7342 -1.2983 Td
(ment)Tj
2.3073 0 Td
(of)Tj
1.0148 0 Td
(microbiota)Tj
4.6205 0 Td
(in)Tj
1.0375 0 Td
(piglets.)Tj
3.0273 0 Td
(There)Tj
2.5739 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(report)Tj
2.7099 0 Td
(showing)Tj
3.5773 0 Td
(that)Tj
1.7802 0 Td
(administration)Tj
6.1681 0 Td
(of)Tj
1.0148 0 Td
(probiotics)Tj
4.2463 0 Td
(to)Tj
-35.5802 -1.3039 Td
(sows)Tj
2.1316 0 Td
(during)Tj
2.9253 0 Td
(gestation)Tj
3.8268 0 Td
(affects)Tj
2.7326 0 Td
(piglet)Tj
2.4377 0 Td
(microbiota)Tj
4.6261 0 Td
(composition)Tj
5.2384 0 Td
(suggesting)Tj
4.4051 0 Td
(a)Tj
0.6519 0 Td
(maternal)Tj
3.7984 0 Td
(influence)Tj
-32.7739 -1.2982 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(On)Tj
1.5137 0 Td
(the)Tj
1.474 0 Td
(other)Tj
2.347 0 Td
(hand,)Tj
2.4832 0 Td
(a)Tj
0.6519 0 Td
(higher)Tj
2.8063 0 Td
(similarity)Tj
4.0025 0 Td
(of)Tj
1.0148 0 Td
(microbiota)Tj
4.6261 0 Td
(between)Tj
3.5263 0 Td
(piglets)Tj
2.8006 0 Td
(co-inhabiting)Tj
5.6296 0 Td
(the)Tj
-34.4747 -1.2983 Td
(same)Tj
2.2563 0 Td
(pen)Tj
1.7121 0 Td
(in)Tj
1.0318 0 Td
(comparison)Tj
4.9776 0 Td
(to)Tj
1.0262 0 Td
(separated)Tj
4.0081 0 Td
(siblings)Tj
3.2429 0 Td
(rather)Tj
2.6475 0 Td
(favors)Tj
2.6362 0 Td
(the)Tj
1.4683 0 Td
(environmental)Tj
6.1115 0 Td
(effect)Tj
2.3641 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
-32.2864 -1.3039 Td
(Various)Tj
3.3845 0 Td
(production)Tj
4.7168 0 Td
(systems,)Tj
3.5263 0 Td
(which)Tj
2.6475 0 Td
(may)Tj
1.9276 0 Td
(affect)Tj
2.3754 0 Td
(gut)Tj
1.5137 0 Td
(microbiota)Tj
4.6204 0 Td
(composition,)Tj
5.4709 0 Td
(are)Tj
1.4456 0 Td
(used)Tj
2.058 0 Td
(in)Tj
1.0375 0 Td
(pig)Tj
-35.9204 -1.2983 Td
(production.)Tj
4.9379 0 Td
(One)Tj
1.9389 0 Td
(example)Tj
3.5489 0 Td
(is)Tj
0.8504 0 Td
(represented)Tj
4.9096 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(conventional)Tj
5.4255 0 Td
(and)Tj
1.7291 0 Td
(organic)Tj
3.2371 0 Td
(farming)Tj
3.4129 0 Td
(systems.)Tj
-32.6435 -1.2983 Td
(However,)Tj
4.0761 0 Td
(when)Tj
2.4038 0 Td
(microbiota)Tj
4.6205 0 Td
(composition)Tj
5.244 0 Td
(in)Tj
1.0375 0 Td
(pigs)Tj
1.8312 0 Td
(in)Tj
1.0318 0 Td
(conventional)Tj
5.4311 0 Td
(or)Tj
1.0942 0 Td
(organic)Tj
3.2371 0 Td
(farming)Tj
3.4129 0 Td
(was)Tj
1.7008 0 Td
(com-)Tj
-35.121 -1.3039 Td
(pared,)Tj
2.7155 0 Td
(there)Tj
2.2677 0 Td
(were)Tj
2.1203 0 Td
(no)Tj
1.2756 0 Td
(extensive)Tj
3.8891 0 Td
(differences)Tj
4.5638 0 Td
(and)Tj
1.7291 0 Td
(microbiota)Tj
4.6204 0 Td
(of)Tj
1.0148 0 Td
(conventional)Tj
5.4312 0 Td
(and)Tj
1.7291 0 Td
(organic)Tj
3.2371 0 Td
(pigs)Tj
-34.5937 -1.2982 Td
(were)Tj
2.1203 0 Td
(alike)Tj
2.0862 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
1.6044 0 Td
(Similarly,)Tj
4.0252 0 Td
(no)Tj
1.2756 0 Td
(significant)Tj
4.388 0 Td
(differences)Tj
4.5694 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(composition)Tj
5.244 0 Td
(of)Tj
1.0148 0 Td
(microbiota)Tj
4.6205 0 Td
(of)Tj
1.0148 0 Td
(indoor)Tj
-34.4634 -1.2983 Td
(and)Tj
1.7291 0 Td
(outdoor)Tj
3.4639 0 Td
(kept)Tj
1.9559 0 Td
(pigs)Tj
1.8312 0 Td
(were)Tj
2.1259 0 Td
(reported)Tj
3.6567 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
1.6044 0 Td
(Various)Tj
3.3789 0 Td
(systems)Tj
3.2995 0 Td
(are)Tj
1.4513 0 Td
(in)Tj
1.0318 0 Td
(use)Tj
1.5364 0 Td
(also)Tj
1.7688 0 Td
(for)Tj
1.3833 0 Td
(rearing)Tj
3.1011 0 Td
(sows)Tj
2.1316 0 Td
(dur-)Tj
-35.4498 -1.3039 Td
(ing)Tj
1.5023 0 Td
(gestation.)Tj
4.0479 0 Td
(The)Tj
1.7801 0 Td
(most)Tj
2.2053 0 Td
(widespread)Tj
4.7565 0 Td
(production)Tj
4.7169 0 Td
(system)Tj
2.9366 0 Td
(is)Tj
0.8504 0 Td
(characterized)Tj
5.5559 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.6519 0 Td
(simple)Tj
2.8573 0 Td
(slatted)Tj
-33.046 -1.2983 Td
(floor)Tj
2.1373 0 Td
(but)Tj
1.5533 0 Td
(alternative)Tj
4.4221 0 Td
(enriched)Tj
3.7303 0 Td
(systems)Tj
3.2995 0 Td
(with)Tj
1.9956 0 Td
(deep)Tj
2.1146 0 Td
(straw)Tj
2.3698 0 Td
(bedding)Tj
3.4866 0 Td
(are)Tj
1.4456 0 Td
(also)Tj
1.7689 0 Td
(in)Tj
1.0374 0 Td
(use.)Tj
1.7575 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(latter)Tj
2.2904 0 Td
(sys-)Tj
-35.9884 -1.2982 Td
(tem,)Tj
1.9842 0 Td
(lower)Tj
2.4548 0 Td
(stress)Tj
2.3924 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(consumption)Tj
5.5446 0 Td
(of)Tj
1.0148 0 Td
(straw)Tj
2.3697 0 Td
(containing)Tj
4.5297 0 Td
(a)Tj
0.652 0 Td
(non-digestible)Tj
5.9584 0 Td
(fiber)Tj
2.0806 0 Td
(may)Tj
1.9276 0 Td
(have)Tj
2.0579 0 Td
(an)Tj
-36.1698 -1.2983 Td
(impact)Tj
2.9763 0 Td
(on)Tj
1.2756 0 Td
(gut)Tj
1.5137 0 Td
(microbiota)Tj
4.6204 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7405 0 Td
(11)Tj
0 g
(].)Tj
1.7348 0 Td
(To)Tj
1.3379 0 Td
(address)Tj
3.2258 0 Td
(this)Tj
1.6725 0 Td
(hypothesis,)Tj
4.6941 0 Td
(here)Tj
1.9616 0 Td
(we)Tj
1.3322 0 Td
(characterized)Tj
5.5559 0 Td
(the)Tj
1.4684 0 Td
(fecal)Tj
-35.1097 -1.3039 Td
(microbiota)Tj
4.6204 0 Td
(of)Tj
1.0148 0 Td
(sows)Tj
2.1316 0 Td
(kept)Tj
1.9559 0 Td
(in)Tj
1.0375 0 Td
(conventional)Tj
5.4255 0 Td
(and)Tj
1.7291 0 Td
(enriched)Tj
3.736 0 Td
(pens)Tj
2.0693 0 Td
(during)Tj
2.9254 0 Td
(gestation.)Tj
4.0478 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8211 0 Td
(we)Tj
-35.6256 -1.2983 Td
(investigated)Tj
4.9889 0 Td
(whether)Tj
3.4752 0 Td
(a)Tj
0.652 0 Td
(maternal)Tj
3.7984 0 Td
(housing)Tj
3.4242 0 Td
(system)Tj
2.9367 0 Td
(may)Tj
1.9276 0 Td
(affect)Tj
2.3754 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4142 0 Td
(of)Tj
1.0148 0 Td
(microbiota)Tj
4.6204 0 Td
(in)Tj
-36.0961 -1.2983 Td
(piglets)Tj
2.7949 0 Td
(during)Tj
2.931 0 Td
(their)Tj
2.109 0 Td
(first)Tj
1.8028 0 Td
(week)Tj
2.2507 0 Td
(of)Tj
1.0148 0 Td
(life.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 421.1716 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Material)Tj
3.959 0 Td
(and)Tj
1.989 0 Td
(Methods)Tj
/F0 1 Tf
-5.948 -1.4976 Td
(Ethical)Tj
3.1842 0 Td
(statement)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 386.1921 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(experiment)Tj
4.7792 0 Td
(was)Tj
1.7008 0 Td
(carried)Tj
3.0387 0 Td
(out)Tj
1.5534 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(experimental)Tj
5.4595 0 Td
(farm)Tj
2.1317 0 Td
(of)Tj
1.0148 0 Td
(Cree)Tj
0 Tc
1.4796 0.051 Td
()Tj
-0.004 Tc
0.4025 -0.051 Td
(com)Tj
1.9673 0 Td
(\(Chambre)Tj
4.3086 0 Td
(d'Agriculture)Tj
-32.0369 -1.2982 Td
(de)Tj
1.1678 0 Td
(Bretagne,)Tj
3.9912 0 Td
(France\).)Tj
3.5149 0 Td
(Animals)Tj
3.583 0 Td
(were)Tj
2.1203 0 Td
(reared)Tj
2.7722 0 Td
(following)Tj
3.9799 0 Td
(French)Tj
3.0387 0 Td
(guidelines)Tj
4.2803 0 Td
(for)Tj
1.3833 0 Td
(animal)Tj
2.9707 0 Td
(care)Tj
1.8708 0 Td
(and)Tj
-34.6731 -1.2983 Td
(use.)Tj
1.7574 0 Td
(The)Tj
1.7802 0 Td
(experimental)Tj
5.4595 0 Td
(protocol)Tj
3.5999 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(Local)Tj
2.3641 0 Td
(Ethics)Tj
2.6702 0 Td
(Committee)Tj
4.7395 0 Td
(for)Tj
1.389 0 Td
(Animal)Tj
-32.0823 -1.3039 Td
(Experiments)Tj
5.2837 0 Td
(in)Tj
1.0375 0 Td
(Rennes)Tj
3.1464 0 Td
(\(Comite)Tj
0 Tc
2.914 0.051 Td
()Tj
-0.004 Tc
0.6236 -0.051 Td
(Rennais)Tj
3.4243 0 Td
(d'Ethique)Tj
4.0818 0 Td
(en)Tj
1.1962 0 Td
(mati)Tj
/F12 1 Tf
[()]TJ
/F6 1 Tf
(re)Tj
3.2428 0 Td
(d'Expe)Tj
0 Tc
2.3188 0.051 Td
()Tj
-0.004 Tc
0.4025 -0.051 Td
(rimentation)Tj
5.0003 0 Td
(Animale\),)Tj
-32.6719 -1.2983 Td
(France,)Tj
3.1747 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(French)Tj
3.0444 0 Td
(Ministry)Tj
3.6793 0 Td
(of)Tj
1.0148 0 Td
(Higher)Tj
3.0444 0 Td
(Education)Tj
4.32 0 Td
(and)Tj
1.7291 0 Td
(Research)Tj
3.8098 0 Td
(\(agreement)Tj
4.7678 0 Td
(n)Tj
1.1622 0 Td
(02805.02\).)Tj
-32.944 -1.2982 Td
(All)Tj
1.3946 0 Td
(sampled)Tj
3.5489 0 Td
(animals)Tj
3.3336 0 Td
(were)Tj
2.1203 0 Td
(returned)Tj
3.7133 0 Td
(back)Tj
2.0806 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(commercial)Tj
4.9549 0 Td
(production)Tj
4.7169 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(end)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-33.5109 -1.3039 Td
(experiment.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 281.9905 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Animals)Tj
3.7323 0 Td
(and)Tj
1.8661 0 Td
(experimental)Tj
5.8725 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Large-White)Tj
5.2837 0 Td
(x)Tj
0.686 0 Td
(Landrace)Tj
3.9174 0 Td
(sows)Tj
2.1373 0 Td
(were)Tj
2.1203 0 Td
(divided)Tj
3.2145 0 Td
(into)Tj
1.8425 0 Td
(2)Tj
0.6973 0 Td
(independent)Tj
5.2724 0 Td
(farrow-to-finish)Tj
6.6444 0 Td
(units)Tj
2.2224 0 Td
(with)Tj
-34.0382 -1.2982 Td
(identical)Tj
3.6566 0 Td
(management)Tj
5.4312 0 Td
(strategies,)Tj
4.1499 0 Td
(but)Tj
1.5533 0 Td
(differing)Tj
3.668 0 Td
(in)Tj
1.0319 0 Td
(the)Tj
1.474 0 Td
(housing)Tj
3.4242 0 Td
(environment)Tj
5.4311 0 Td
(for)Tj
1.3833 0 Td
(gestating)Tj
3.7814 0 Td
(sows.)Tj
-34.9849 -1.2983 Td
(Pens)Tj
2.1089 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(conventional)Tj
5.4255 0 Td
(unit)Tj
1.8652 0 Td
(were)Tj
2.1203 0 Td
(furnished)Tj
4.0648 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6577 0 Td
(concrete)Tj
3.6339 0 Td
(slatted)Tj
2.812 0 Td
(floor)Tj
2.1373 0 Td
(with)Tj
2.0013 0 Td
(2.4)Tj
1.3946 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 535.4645 243.4393 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 541.1905 239.0173 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(space)Tj
-34.1175 -1.3039 Td
(per)Tj
1.5307 0 Td
(sow,)Tj
1.9955 0 Td
(and)Tj
1.7348 0 Td
(pens)Tj
2.0693 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(enriched)Tj
3.7304 0 Td
(unit)Tj
1.8652 0 Td
(were)Tj
2.1203 0 Td
(covered)Tj
3.3505 0 Td
(with)Tj
1.9956 0 Td
(deep)Tj
2.1146 0 Td
(straw)Tj
2.3698 0 Td
(with)Tj
1.9956 0 Td
(more)Tj
2.3414 0 Td
(space)Tj
2.381 0 Td
(per)Tj
1.5306 0 Td
(ani-)Tj
-35.6311 -1.2982 Td
(mal)Tj
1.7178 0 Td
(\(3.4)Tj
1.7347 0 Td
(m)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 242.759 217.4173 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 248.5417 212.9952 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(per)Tj
1.5306 0 Td
(sow\).)Tj
2.3358 0 Td
(All)Tj
1.4003 0 Td
(sows)Tj
2.1316 0 Td
(were)Tj
2.1203 0 Td
(transferred)Tj
4.6375 0 Td
(to)Tj
1.0261 0 Td
(identical)Tj
3.6567 0 Td
(individual)Tj
4.2859 0 Td
(farrowing)Tj
4.1613 0 Td
(crates)Tj
2.5285 0 Td
(\(2.25)Tj
2.211 0 Td
(x)Tj
-36.8784 -1.2982 Td
(0.5)Tj
1.3889 0 Td
(m\))Tj
1.3777 0 Td
(with)Tj
1.9899 0 Td
(a)Tj
0.6518 0 Td
(slatted)Tj
2.8063 0 Td
(floor)Tj
2.1317 0 Td
(at)Tj
0.9467 0 Td
(gestation)Tj
3.8211 0 Td
(day)Tj
1.6327 0 Td
(105.)Tj
1.8652 0 Td
(When)Tj
2.6816 0 Td
(needed,)Tj
3.3165 0 Td
(piglet)Tj
2.4321 0 Td
(adoptions)Tj
4.1839 0 Td
(were)Tj
2.1203 0 Td
(performed)Tj
-33.3464 -1.3039 Td
(among)Tj
2.9933 0 Td
(litters)Tj
2.4831 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2563 0 Td
(treatment)Tj
4.1329 0 Td
(group)Tj
2.6135 0 Td
(to)Tj
1.0205 0 Td
(equalize)Tj
3.4639 0 Td
(the)Tj
1.4684 0 Td
(size)Tj
1.6837 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(litters.)Tj
2.7099 0 Td
(Common)Tj
4.0819 0 Td
(proce-)Tj
-33.885 -1.2983 Td
(dures)Tj
2.4321 0 Td
(\(iron)Tj
2.2507 0 Td
(injection,)Tj
3.9854 0 Td
(tooth)Tj
2.3584 0 Td
(grinding,)Tj
3.9061 0 Td
(tail)Tj
1.4683 0 Td
(resection,)Tj
4.0705 0 Td
(castration\))Tj
4.5014 0 Td
(were)Tj
2.1203 0 Td
(applied)Tj
3.1521 0 Td
(between)Tj
3.532 0 Td
(24)Tj
1.1679 0 Td
(and)Tj
-34.9452 -1.2983 Td
(72)Tj
1.1678 0 Td
(hours)Tj
2.5172 0 Td
(after)Tj
2.0351 0 Td
(birth.)Tj
2.4151 0 Td
(Sows)Tj
2.2507 0 Td
(were)Tj
2.1203 0 Td
(fed)Tj
1.457 0 Td
(a)Tj
0.6577 0 Td
(standard)Tj
3.719 0 Td
(gestation)Tj
3.8268 0 Td
(and)Tj
1.7291 0 Td
(lactation)Tj
3.6793 0 Td
(diet.)Tj
-26.3789 -1.2982 Td
(The)Tj
1.7858 0 Td
(experiment)Tj
4.7791 0 Td
(was)Tj
1.6951 0 Td
(repeated)Tj
3.6396 0 Td
(on)Tj
1.2756 0 Td
(3)Tj
0.6973 0 Td
(replicates)Tj
3.9855 0 Td
(with)Tj
1.9956 0 Td
(3)Tj
0.6973 0 Td
(different)Tj
3.6567 0 Td
(batches)Tj
3.1918 0 Td
(of)Tj
1.0148 0 Td
(sows)Tj
2.1373 0 Td
(that)Tj
1.7745 0 Td
(farrowed)Tj
-33.5222 -1.3039 Td
(in)Tj
1.0318 0 Td
(April)Tj
2.3074 0 Td
(2014,)Tj
2.3469 0 Td
(September)Tj
4.4844 0 Td
(2014)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(January)Tj
3.3222 0 Td
(2015.)Tj
2.3471 0 Td
(Fecal)Tj
2.2734 0 Td
(samples)Tj
3.3845 0 Td
(were)Tj
2.1203 0 Td
(collected)Tj
3.7417 0 Td
(from)Tj
2.2054 0 Td
(sows)Tj
-33.4145 -1.2983 Td
(during)Tj
2.9253 0 Td
(farrowing)Tj
4.1555 0 Td
(\(sows)Tj
2.4774 0 Td
(originating)Tj
4.6545 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4683 0 Td
(conventional)Tj
5.4255 0 Td
(system:)Tj
3.1635 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7993 0 Td
(6,)Tj
0.9185 0 Td
(6)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(6,)Tj
0.9241 0 Td
(and)Tj
1.7291 0 Td
(from)Tj
-34.0494 -1.2983 Td
(the)Tj
1.4683 0 Td
(enriched)Tj
3.7303 0 Td
(system:)Tj
3.1634 0 Td
(n)Tj
0.771 0 Td
(=)Tj
0.7994 0 Td
(6,)Tj
0.9241 0 Td
(8)Tj
0.6916 0 Td
(and)Tj
1.7348 0 Td
(7,)Tj
0.9185 0 Td
(in)Tj
1.0374 0 Td
(batch)Tj
2.4095 0 Td
(1,)Tj
0.9184 0 Td
(2)Tj
0.6973 0 Td
(and)Tj
1.7291 0 Td
(3,)Tj
0.9241 0 Td
(respectively\).)Tj
5.4482 0 Td
(Fecal)Tj
2.2733 0 Td
(samples)Tj
3.3846 0 Td
(were)Tj
2.1203 0 Td
(col-)Tj
-35.1436 -1.3039 Td
(lected)Tj
2.5625 0 Td
(from)Tj
2.2053 0 Td
(piglets)Tj
2.8005 0 Td
(on)Tj
1.2756 0 Td
(day)Tj
1.6328 0 Td
(1)Tj
0.6973 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4456 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(first)Tj
1.8029 0 Td
(replicate)Tj
3.6283 0 Td
(\(13)Tj
1.508 0 Td
(piglets)Tj
2.8006 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(6)Tj
0.6973 0 Td
(sows)Tj
2.1316 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(con-)Tj
-34.8658 -1.2983 Td
(ventional)Tj
3.9458 0 Td
(system)Tj
2.9365 0 Td
(and)Tj
1.7348 0 Td
(11)Tj
1.1679 0 Td
(piglets)Tj
2.8006 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(6)Tj
0.6974 0 Td
(sows)Tj
2.1316 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(enriched)Tj
3.736 0 Td
(system\).)Tj
3.5036 0 Td
(Fecal)Tj
2.2734 0 Td
(samples)Tj
3.3845 0 Td
(were)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 470.211 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Microbiota)Tj
4.748 0 Td
(of)Tj
1.0418 0 Td
(Sows)Tj
2.6291 0 Td
(and)Tj
1.8567 0 Td
(Piglets)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0170)Tj
3.5434 0 Td
(051)Tj
2.6362 0 Td
(January)Tj
3.7134 0 Td
(13,)Tj
1.5874 0 Td
(2017)Tj
37.8003 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(10)Tj
/F10 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(company)Tj
3.6567 0 Td
(did)Tj
1.3606 0 Td
(not)Tj
1.4244 0 Td
(fund)Tj
1.8922 0 Td
(work)Tj
2.0622 0 Td
(presented)Tj
3.8906 0 Td
(in)Tj
0.8858 0 Td
(this)Tj
-15.1725 -1.3748 Td
(manuscript)Tj
4.4149 0 Td
(at)Tj
0.893 0 Td
(all.)Tj
1.2543 0 Td
(The)Tj
1.5874 0 Td
(funder)Tj
2.6221 0 Td
(provided)Tj
3.4583 0 Td
(partial)Tj
-14.23 -1.3749 Td
(support)Tj
3.0968 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3748 0 Td
(form)Tj
2.0055 0 Td
(of)Tj
0.9496 0 Td
(salaries)Tj
3.0189 0 Td
(for)Tj
1.2615 0 Td
(authors)Tj
3.0401 0 Td
(IR,)Tj
1.2898 0 Td
(but)Tj
-16.9229 -1.3748 Td
(did)Tj
1.3606 0 Td
(not)Tj
1.4244 0 Td
(have)Tj
1.9559 0 Td
(any)Tj
1.5378 0 Td
(additiona)Tj
3.3733 0 Td
(l)Tj
0.4181 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2678 0 Td
(design,)Tj
-16.2072 -1.3748 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.7347 0 Td
(and)Tj
1.5945 0 Td
(analysis)Tj
2.9622 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2883 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-17.9151 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
4.6347 0 Td
(The)Tj
1.5945 0 Td
(specific)Tj
3.0189 0 Td
(roles)Tj
2.0339 0 Td
(of)Tj
-18.0426 -1.3748 Td
(these)Tj
2.211 0 Td
(authors)Tj
3.0473 0 Td
(are)Tj
1.3677 0 Td
(articulated)Tj
4.0606 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(`author)Tj
-12.9402 -1.3748 Td
(contributio)Tj
3.9897 0 Td
(ns')Tj
1.3111 0 Td
(section.)Tj
/F9 1 Tf
-5.3008 -2.126 Td
(Competing)Tj
4.3795 0 Td
(Interests)Tj
3.3307 0 Td
(:)Tj
/F10 1 Tf
0.4819 0 Td
(Partici)Tj
2.3103 0 Td
(pation)Tj
2.5158 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
-13.9678 -1.3748 Td
(commercial)Tj
4.5779 0 Td
(partner)Tj
2.8843 0 Td
(did)Tj
1.3607 0 Td
(not)Tj
1.4173 0 Td
(influence)Tj
3.5504 0 Td
(relevant)Tj
-13.7906 -1.3749 Td
(declaratio)Tj
3.5787 0 Td
(ns)Tj
1.1197 0 Td
(relating)Tj
2.9552 0 Td
(to)Tj
0.9496 0 Td
(employment)Tj
4.6417 0 Td
(,)Tj
0.4465 0 Td
(consultan)Tj
3.6 0 Td
(cy,)Tj
-17.2914 -1.3748 Td
(patents,)Tj
3.1677 0 Td
(products)Tj
3.515 0 Td
(in)Tj
0.8858 0 Td
(development)Tj
4.7835 0 Td
(,)Tj
0.4465 0 Td
(or)Tj
0.9992 0 Td
(marketed)Tj
-13.7977 -1.3748 Td
(products,)Tj
3.7417 0 Td
(etc.)Tj
1.5449 0 Td
(The)Tj
1.5874 0 Td
(commercial)Tj
4.578 0 Td
(partner)Tj
2.8843 0 Td
(also)Tj
1.7291 0 Td
(did)Tj
1.3607 0 Td
(not)Tj
-17.4261 -1.3748 Td
(alter)Tj
1.8212 0 Td
(our)Tj
1.4741 0 Td
(adherenc)Tj
3.4086 0 Td
(e)Tj
0.6449 0 Td
(to)Tj
0.9496 0 Td
(PLOS)Tj
2.3316 0 Td
(ONE)Tj
1.8637 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
-15.5056 -1.3748 Td
(sharing)Tj
2.9834 0 Td
(data)Tj
1.793 0 Td
(and)Tj
ET
endstream
endobj
22 0 obj
<>stream
endstream
endobj
23 0 obj
<>stream
endstream
endobj
24 0 obj
<>stream
endstream
endobj
25 0 obj
<>stream
endstream
endobj
26 0 obj
<>stream
endstream
endobj
27 0 obj
<>stream
endstream
endobj
28 0 obj
<>stream
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
BT
6.3638 64.0918 Td
(materials.)Tj
ET
Q
endstream
endobj
31 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 36 0 R/Contents 37 0 R/TrimBox[0 0 612 792]>>
endobj
33 0 obj
<>
endobj
38 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
14 beginbfchar
<0010><002D>
<0016><0033>
<0018><0035>
<0024><0041>
<0026><0043>
<0027><0044>
<002A><0047>
<002B><0048>
<002C><0049>
<0030><004D>
<0031><004E>
<0037><0054>
<0039><0056>
<003A><0057>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
39 0 obj
<>/FontDescriptor 40 0 R/DW 600>>
endobj
40 0 obj
<>
endobj
41 0 obj
<>stream
`DSIG EBDTL\ iX EBLC+\ mL 4GDEF̥
r GSUBLcu| s NOS/2
0M VVDMX2M' B bdatL\ bloc+\ 4cmapX[ Bcvt a d fpgm62 _ gasp + @ glyf v head)x l 6hhea{<